A single supratherapeutic dose of ridaforolimus does not prolong the QTc interval in patients with advanced cancer
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چکیده
منابع مشابه
A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer.
PURPOSE This dedicated QTc phase I study, conducted in advanced-stage cancer patients, assessed the effect of a single supratherapeutic dose (800 mg) of vorinostat on the QTc interval. EXPERIMENTAL DESIGN A randomized, partially blind, placebo-controlled, two-period, crossover study was conducted. Patients (n = 25) received single doses of 800 mg vorinostat and placebo in the fasted state. Ho...
متن کاملExenatide at therapeutic and supratherapeutic concentrations does not prolong the QTc interval in healthy subjects
AIMS Exenatide has been demonstrated to improve glycaemic control in patients with type 2 diabetes, with no effect on heart rate corrected QT (QTc ) at therapeutic concentrations. This randomized, placebo- and positive-controlled, crossover, thorough QT study evaluated the effects of therapeutic and supratherapeutic exenatide concentrations on QTc . METHODS Intravenous infusion was employed t...
متن کاملA thorough QTc study demonstrates that olmesartan medoxomil does not prolong the QTc interval
Two studies (ROADMAP and ORIENT) evaluating the renoprotective effects of olmesartan medoxomil (OM) in patients with type 2 diabetes suggested OM is associated with increased cardiovascular mortality. We conducted a thorough QTc study to evaluate the effects of OM on cardiac repolarization. A randomized, double-blind, phase 1 study was conducted per E14 Guidance to assess the effects of single ...
متن کاملLenalidomide at Therapeutic and Supratherapeutic Doses Does Not Prolong QTc Intervals in the Thorough QTc Study Conducted in Healthy Men
The effect of lenalidomide on the corrected QT (QTc) interval was evaluated in healthy men and extended to patients based on the lenalidomide concentration-QTc (C-QTc) relationship. A rigorous assessment of the effect of lenalidomide on QTc intervals was conducted in healthy volunteers who each received, in randomized order, a single oral dose of 10 mg lenalidomide, 50 mg lenalidomide, 400 mg m...
متن کاملErratum to: Albiglutide Does Not Prolong QTc Interval in Healthy Subjects: A Thorough ECG Study
The authors of the above mentioned manuscript would like to make the following clarification. The associated ClinicalTrials.gov registration number for this GlaxoSmithKline trial ‘‘Albiglutide Thorough ECG Study in Healthy Volunteers’’ was inadvertently omitted within the previously published results. The full registration number for this trial is NCT01406262. Open Access. This article is distr...
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ژورنال
عنوان ژورنال: Cancer Chemotherapy and Pharmacology
سال: 2012
ISSN: 0344-5704,1432-0843
DOI: 10.1007/s00280-012-1942-7